Insulin-based regulation of glucose-functionalized nanoparticle uptake in muscle cells
نویسندگان
چکیده
منابع مشابه
Insulin-Based Regulation of Glucose-functionalized Nanoparticle Uptake in Muscle Cells.
Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the p...
متن کاملRegulation of Glucose Uptake in Muscle
It was concluded in earlier papers (l-7) that the transport of glucose through the cell membrane and the phosphorylation of free glucose inside the cell are the major rate-controlling steps for glucose uptake by the heart. In the muscle from severely diabetic animals, glucose uptake was very low. This could be attributed to a low rate of transport, which is principally limiting for uptake under...
متن کاملRegulation of Glucose Uptake by Muscle
In previous papers (Randle & Smith, 1958a, b) evidence was presented that insulin, anoxia and substances such as salicylate or 2:4-dinitrophenol, which inhibit oxidative phosphorylation, increase the uptake of glucose and D-xylose by isolated rat diaphragm by accelerating the transfer of these sugars across the muscle-cell membrane. The conclusion was drawn that the transfer process for sugars ...
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Physiological stressors such as sepsis and tissue damage initiate an acute immune response and cause transient systemic insulin resistance. This study was conducted to determine whether tumor necrosis factor-alpha (TNF-alpha), a cytokine produced by immune cells during skeletal muscle damage, decreases insulin responsiveness at the cellular level. To examine the molecular mechanisms associated ...
متن کاملRegulation of glucose uptake in differentiated cells.
Glucose uptake into the cell is mediated by a family of glycosylated membrane proteins, called glucose transporters (GTs) that are able to facilitate passive hexose transfer across the lipid plasma membrane. The tissue-specific transporter isoforms generally differ in their affinity to the natural substrate D-glucose according to the specific functions of the respective organ. The mechanisms by...
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ژورنال
عنوان ژورنال: Journal of Materials Chemistry B
سال: 2014
ISSN: 2050-750X,2050-7518
DOI: 10.1039/c4tb00608a